肖海华

姓名：肖海华 职称：研究员/博导 单位：中国科学院化学研究所 邮件：hhxiao@iccas.ac.cn

 

个人简介

肖海华，博士，83年生，湖南衡阳人，高分子物理与化学国家重点实验室研究员。2012年于中国科学院长春应用化学研究所博士毕业后先后到美国圣母大学（2012-2014）、麻省理工学院（2014-2017）从事博士后研究。近年来，聚焦生物医用高分子的合成及其应用进行了一系列研究，工作主要围绕药物传输、基因治疗和基因编辑、免疫治疗和精准治疗等展开。

 

研究领域

基于生物医用高分子的肿瘤抗耐药和抗转移载药体系

基于生物医用高分子的精准医疗、个性化治疗和免疫治疗体系

基于生物医用高分子的基因编辑技术研究

高分子基因和药物传输体系的深层次作用机制研究

 

教育经历

2002.9–2006.7 湘潭大学高分子材料与工程系 工学学士

2006.9-2012.7 中国科学院长春应用化学研究所（导师: 景遐斌 研究员 陈学思研究员） 理学博士

 

工作经历

2012.9–2014.8 美国圣母大学生物医学工程系 博士后

2014.9–2017.7 美国麻省理工学院科郝癌症研究所 博士后

2017.8–2017.11 中国科学院化学研究所 高级访问学者  

2017.12–至今 中国科学院化学研究所 研究员

 

代表论文

1. Lang Rao; Guang‐Tao Yu; Qian‐Fang Meng; Lin‐Lin Bu; Rui Tian; Li‐Sen Lin; Hongzhang Deng; Weijing Yang; Minghui Zan; Jianxun Ding; Andrew Li; Haihua Xiao(*); Zhi‐Jun Sun(*); Wei Liu(*); Xiaoyuan Che(*),Cancer Cell Membrane‐Coated Nanoparticles for Personalized Therapy in Patient‐Derived Xenograft Models, Adv. Funct. Mater, 2019, 1905671.

2. Jiaxu Li; Liuchun Zheng(*); Haihua Xiao(*); Chuncheng Li(*); Shaohua Wu; Yaonan Xiao; Jiajian Liua and Bo Zhanga, Design of zwitterionic polyester based nanocarriers for platinum(IV) prodrug delivery, Polymer Chemistry, 2019, 10, 5353

3. Tiantian Wu; Jianbing Liu; Manman Liu; Shaoli Liu; Shuai Zhao; Run Tian; Dengshuai Wei; Yangzhong Liu; Yao Zhao; Haihua Xiao; Baoquan Ding(*),A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum Drug Delivery, Angew. Chem. Int. Ed, 2019, DOI: 10.1002/anie.201909345

4. Binbin Ding; Shuai Shao; Haihua Xiao;Chunqiang Sun; Xuechao Cai; Fan Jiang; Xueyan Zhao; Ping'an Ma (*), and Jun Lin (*),MnFe2O4-decorated large-pore mesoporous silica-coated upconversion nanoparticles for near-infrared light-induced and O2 self-sufficient photodynamic therapy, Nanoscale, 2019.7.18, DOI:10.1039 / C9NR04858H

5. Guyu Zhang; Yimin Zhu; Yushu Wang; Dengshuai Wei; Yixin Wu;Liuchun Zheng; Huimin Bai(*), Haihua Xiao(*), and Zhenyu Zhang, pH/redox sensitive nanoparticles with platinum(IV) prodrugs and doxorubicin enhance chemotherapy in ovarian cancer, RSC Adv, 2019.7.2, 9, 20513-20517

6. Lawrence B. Mensah; Stephen W. Morton; Jiahe Li ; Haihua Xiao ; Mohiuddin A. Quadir ; Kevin M. Elias ; Emily Penn ; Aysen K. Richson ; Paiman Peter Ghoroghchian ; Joyce Liu ; Paula T. Hammond (*), Layer-by-layer nanoparticles for novel delivery of cisplatin and PARP inhibitors for platinum-based drug resistance therapy in ovarian cancer, Bioengineering & Translational Medicine, 2019.5.15, 4(2): e10131

7. Xiaoxu Kang; Yingjie Yu; Zhigang Chen; Yixin Wu; Dengshuai Wei; Yao Zhao; Fuyi Wang ; Haihua Xiao(*), A negatively charged Pt(IV) prodrug for electrostatic complexation with polymers to overcome cisplatin resistance, J. Mater. Chem. B, 2019.4.18, 7, 3346

8. Yuhua Weng; Haihua Xiao; Jinchao Zhang; Xing-Jie Liang;Yuanyu Huang(*), RNAi therapeutic and its innovative biotechnological evolution,Biotechnology Advances, 2019.04.12, 37(5):801-825

9. Lu Liu; Fanlei Hu; Hui Wang; Xiaoli Wu; Ahmed Shaker Eltahan; Stephanie Stanford; Nunzio Bottini; Haihua Xiao(*);Massimo Bottini(*); Xing-Jie Liang(*),Secreted Protein Acidic and Rich in Cysteine Mediated Biomimetic Delivery of Methotrexate by Albumin-Based Nanomedicines for Rheumatoid Arthritis Therapy, ACS Nano, 2019.04.12, 13(5): 5036-5048.

10. Zhigang Chen; Xiaoxu Kang; Yixin Wu ; Haihua Xiao; Xuzi Cai; Shihou Sheng(*), Xuefeng Wang(*), and Shiguo Chen(*), A mitochondria targeting artesunate prodrugloaded nanoparticle exerting anticancer activity via iron-mediated generation of the reactive oxygen species,Chem. Commun, 2019.3.20 ,55, 4781

11. Yu,Yingjie(#); Xu,Quan(#); He,Shasha; Xiong,Hejian; Zhang,Qingfei; Xu,Weiguo; Ricotta,Vincent; Bai, Lei; Zhang,Qi; Yu,Zhiqiang; Ding,Jianxun(*); Xiao,Haihua(*); Zhou,Dongfang(*), Recent Advances in Delivery of Photosensitive Metal-Based Drugs, Coordination Chemistry Reviews, 2019.02.23, 387: 154-179